2021 Oct 27;13(11):3836. doi: 10.3390/nu13113836. The powder is available for quick mixing with any liquid or even for pouring into a meal such as oatmeal or apple sauce. These same benefits can also be seen in children and adults. The human milk oligosaccharide 2-fucosyllactose modulates Int J Nanomedicine. Get first access to new product launches, sales and exclusive content. Free Shipping in the U.S. on Orders Over $45.00 + We Ship Worldwide. Role of milk glycome in prevention, treatment, and recovery of COVID-19. PureHMO Prebiotic Powder has also received high praise from customers in both reviews and on social media where fans post pictures once their order arrives and is in hand! exhibit prebiotic properties on cultured infant microbiota. A "Study found that 30% of babies' beneficial bacteria come from their . The Human Milk Oligosaccharide 2'-Fucosyllactose Alleviates Liver Steatosis, ER Stress and Insulin Resistance by Reducing Hepatic Diacylglycerols and Improved Gut Permeability in Obese Ldlr-/-.Leiden Mice. Because there is always some risk involved, the author cannot be responsible for any adverse effects or consequences resulting from the use of any of the suggestions, preparations, supplements or procedures described on this website. HHS Vulnerability Disclosure, Help Rudloff S, Pohlentz G, Borsch C, Lentze MJ, Kunz C. Urinary excretion of in vivo (1)(3)Clabelled J Leukoc Biol. The most abundant HMO in human milk is 2'-fucosyllactose (2'-FL), which is negligible in cow's milk. In vitro assays have demonstrated that HMOs impact gut microbiota composition, barrier function and immune modulation. Int J Mass Spectrom. -, Egge H., Dell A., Von Nicolai H. Fucose containing oligosaccharides from human milk. 2016 Oct;116(8):1356-1368. doi: 10.1017/S0007114516003354. official website and that any information you provide is encrypted The .gov means its official. 7. Human milk oligosaccharides (HMO) have attracted great interest in recent years due to their role in boosting infants and adults health. 2019;90:191201. Oligosaccharides can be naturally found in human milk and various plant foods. As a supplement, all people can benefit from HMOs, specifically in the prevention of leaky gut and the promotion of overall gut and digestive health. and B.M.C. 5 min read. 2019;68:256263. 2000;47:646-652. HMOs are usually about 3-32 monosaccharides long having lactose at their reducing terminus, linked via glycosidic bonds in glycosyltransferases catalysed reaction (Bertino et al . HMOs) are the third most abundant component in breast milk (excluding water), after fat and carbohydrates. All we can say is these capsules from Layer Origin work, they really do! Shaping the gut microbiome. Human milk oligosaccharides inhibit the Glycobiology. Presence of gene clusters implicated in digestion of human milk oligosaccharides (HMOs) varied between species, with growth studies indicating that within single infants there were differences in . Gut. Keywords: SHIME; adult gut microbiota; gut barrier function; gut-on-chips; human milk oligosaccharides. After partnering with a fellow food scientist and nutritionist, Layer Origin Natural Supplements was formed. 2004;145:297- No wonder breast milk has always been the gold standard for infant nutrition. The findings indicated that HMOs could provide significant benefits for adult gut health. Isotopes Environ Health Stud. Clipboard, Search History, and several other advanced features are temporarily unavailable. Pediatr. Macri S, Hauser J, 2019. An animal study at Abbott's labs showed that HMO stimulated the. 24. The data show results for FD4 concentration in basolateral medium (g/mL) of f-2FL/C, f-2FL/Tw1&2, f-2FL/Tw3, f-LNnT/C, f-LNnT/T, f-MIX/C, and f-MIX/T, medium-only treated Caco2 cells (BL) and butyrate as the control. Gut. both produce enzymes that are particularly effective at this. They are also approved as Novel Foods in the EU and Canada, and are authorised for use in some Asian countries. One pilot study on patients with irritable bowel syndrome (IBS) showed an effect from 2-FL on gastrointestinal symptoms, faecal microbiota and short chain fatty acids, while an open-label, single arm study (a simple study design in which the volunteers were aware of the treatment being given) also showed improvement in bowel function and IBS symptoms. 2009;101:1306-1315. [1] The HMO profile of human breast milk shapes the gut microbiota of the infant by selectively stimulating bifidobacteria and other bacteria. Human milk oligosaccharides (HMOs) are specific carbohydrates, and essentially super prebiotics occurring naturally in mother's milk. bifidobacteria; human milk oligosaccharides; infections; nutrition; prebitics. But there are still many questions: for example, one large study found no difference between infants who were fed formula with or without HMOs in terms of the number of respiratory tract infections or the duration of gastrointestinal infections. doi: 10.1097/MPG.0000000000002216. J. Agric. Human milk oligosaccharides improve 'leaky' guts Human milk oligosaccharides (HMOs) in breast milk shape the healthy gut microbiota of infants. In 2017, Layer Origin's Chief Scientist was a post-doctoral fellow at Cornell University in the food science program. Nutr. Designed by attitude inc design | Copyright 1999-2021 Dr. David Dahlman. 2004;56:536-540. Food Analytics (The Protective and Long-Lasting Effects of Human Milk Oligosaccharides on Cognition in Mammals, Nutrients, 2020), November 16, 2022 The role of breast milk in prevention and treatment. Benefits of human milk Human milk provides all the essential components for the growth and development of the baby. We tried another HMO product from another company with less than positive results. In regulatory sense human milk oligosaccharides are classified as novel foods or novel food ingredients requiring safety assessment. I found your brand and within 2 weeks started seeing improvements in a 1 year ongoing hip pain. 2022 Oct 11;12:1054190. doi: 10.3389/fcimb.2022.1054190. 2004;76:820-826. Alwine Kardinaal (AK): "HMOs are non-digestible carbohydrates, and the third most abundant component of human breast milk, after lipids and lactose. Pediatr. Ruiz-Palacios GM, Cervantes LE, Ramos P, Chavez-Munguia B, Newburg DS. -, Bode L. Human Milk Oligosaccharides: Next-Generation Functions and Questions. Thankfully, in 2020 Layer Origin Natural Supplements launched its line of Human Milk Oligosaccharide products specifically designed for adults (and teens or children) who want to bolster their gut health, immune system, and cognitive function. On an average, human milk has 12-14 g l 1 of oligosaccharides in mature milk and 20-23 g l 1 in colostrum (Coppa et al. The author urges you to consult with your physician or other qualified health-care provider prior to starting any treatment or undergoing any surgical procedure. The data show, Impact of f-HMO treatment on cytokine secretion of Caco2 cells. Gart E, Salic K, Morrison MC, Giera M, Attema J, de Ruiter C, Caspers M, Schuren F, Bobeldijk-Pastorova I, Heer M, Qin Y, Kleemann R. Front Nutr. The 2^(Ct) method data are shown for Caco2 cells grown on transwells that were treated with f-2FL (, Effect of the f-HMO treatment on gene expression of barrier function proteins of the gut-on-chip. The powder has been recognized as a great value with its 45 servings vs. just 30 servings available with the capsules (90 capsules per bottle at 3/capsules per serving). 17. 1996;408:1-8. Moya-Alvarez V, Eussen SRBM, Mank M, Koyembi JJ, Nyasenu YT, Ngaya G, Mad-Bondo D, Kongoma JB, Stahl B, Sansonetti PJ, Bourdet-Sicard R. Front Nutr. eCollection 2022. 12. Human milk oligosaccharides market size is expected to reach USD 332.4 Million in the year 2030 and expected to grow at a CAGR of 14.4% during the assessment period. Kuntz S, Rudloff S, Kunz C. Oligosaccharides from human milk influence growth-related Using gut-on-chips generated from human organoids derived from proximal, transverse, and distal colon biopsies (Colon Intestine Chips), we showed that claudin-5 was significantly upregulated across all three gut-on-chips following treatment with fermented 2'FL under microfluidic conditions. Formula makers champion the addition of HMOs to their products as a groundbreaking step, because the HMOs are structurally identical to the HMOs in breast milk. The site is secure. 9. They are similar to oligosaccharides and prebiotics from other sources, which are known to promote a healthy gut microbiome and immune system. 19. Human milk oligosaccharides (HMOs) are the third main in- . One could also purchase baby formula and drink that to get some HMOs, but it would come with lots of filler that is not meant for adults, nor needed in any way. Eiwegger T, Stahl B, Schmitt J, et al. This mucosal barrier prevents undesirable substances from being absorbed into the body, while letting nutrients pass. 2017 Feb 9;12(2):e0171814. These synthetic versions are already used in infant formulas, and are available for some other applications. 2018 Sep 21;10(10):1346. doi: 10.3390/nu10101346. Glycobiology. I wasn't expecting joint pain improvement through gut health. Thanks so much! Identifying human milk glycans that inhibit norovirus PMC -. Nutrients. So, if you don't have enough existing probiotic bacteria, the prebiotics might go to waste. 2012;22:11471162. Human milk glycans protect infants against HMOs also stimulate the gut bacteria to produce short chain fatty acids, which strengthen the guts mucous membrane. Black points and error bars (95% confidence levels) represent estimates of treatment effect as compared with BL, with outcomes scaled such that the horizontal line at y = 1 represents the average BL level. Ser B Phys Biol Sci. Because these concentrations are so variable and abundant, the . doi: 10.1891/0730-0832.32.3.175. You can think of HMOs as a nonstick . The https:// ensures that you are connecting to the Specifically, adults dealing with leaky gut, IBS, SIBO, and other ailments might find relief, if consuming HMOs. Food manufacturers also artificially add them to packaged foods to enhance their flavor, texture, or prebiotic . Human Milk Oligosaccharides Market Overview. Comparison of FD4 permeability for each f-HMO to BL is shown. Human milk oligosaccharides (HMOs) are compound indigestible sugars found in human milk. This article will discuss the mechanisms of action of HMOs in infants, such as their anti-adhesive properties, properties modulating the immune system, and impact on bacterial flora development. Furthermore, like other prebiotics, HMOs may support immune function. Clipboard, Search History, and several other advanced features are temporarily unavailable. Haemost. Effects of Human Milk Oligosaccharides on the Adult Gut Microbiota and Barrier Function. Previously, only babies who were breastfed got HMOs and their inherent benefits. Glycoprofiling with micro-arrays of glycoconjugates 303. They are a structurally and biologically diverse group of complex indigestible sugars. Biophys. All rights reserved. "They are similar to oligosaccharides and prebiotics from other sources, which are known to promote a healthy gut microbiome and immune system. I was just trying to heal my gut. The major benefit is the unique natural immune-nourishing human milk oligosaccharides prebiotics and beyond, including cognitive and developmental properties. 8600 Rockville Pike structural, functional, and metabolic aspects. Human Milk Oligosaccharides Health Benefits, Viberzi is a New Medicine for IBS with Diarrhea, Common Heartburn Drugs Linked with Kidney Disease. AK: After decades of research and development, we finally have adequate sources of synthetic HMOs both for testing and, ultimately, commercialisation. All three of these top Human Milk Oligosaccharide products designed for adults are available on Amazon and on the Layer Origin Nutrition website. and toxins and by directly binding to epithelial receptors. 2022 Oct 28;12:991150. doi: 10.3389/fcimb.2022.991150. Breast milk contains a plethora of molecules among which include human milk oligosaccharides (HMOs), polyunsaturated fatty acids, proteins, hormones, vitamins, and cytokines . Modulation of 3'-SL level in pre-weaning milk impact attention, learning and memory in the adult offspring. SHIME; adult gut microbiota; gut barrier function; gut-on-chips; human milk oligosaccharides. Both PureHMO Capsules and PureHMO Powder are versatile in their own ways. 3. Disclaimer, National Library of Medicine characteristics of intestinally transformed and non-transformed intestinal cells. In 2020, Layer Origin launched PureHMO Prebiotic. Many health benefits result from consuming HMOs. 3 The company's HMO is called PureHMO because of its high purity. Human milk-derived oligosaccharides and plant derived Engfer MB, Stahl B, Finke B, Sawatzki G, Daniel H. Human milk oligosaccharides are Elison E, Vigsnaes LK, Rindom Krogsgaard L, Rasmussen J, Srensen N, McConnell B, Hennet T, Sommer MO, Bytzer P. Br J Nutr. They confuse these organisms causing them to bind to the HMO and not human cells. associated with protection against diarrhea in breast-fed infants. adults with 2'-O-fucosyllactose and lacto-N-neotetraose is well tol- We showed that fermentation of 2'-O-fucosyllactose (2'FL), lacto-N-neotetraose (LNnT), and combinations thereof (MIX) led to an increase of bifidobacteria, accompanied by an increase of short chain fatty acid (SCFA), in particular butyrate with 2'FL. Separation and identification of new constituents. Among the many important components of human milk are human milk oligosaccharides (HMOs): complex carbohydrates that are 3-32 sugars in length. Layer Origin's powdered HMO allows you to scoop your serving into any type of food or beverage. The gold standard in infant nutrition, breast milk, has been shown to reduce the incidence of infectious diseases and allergies in infants. enteric pathogens. PureHMO Prebiotic is Layer Origin's original and best-selling HMO supplement for adults that comes in capsules. For the next three to four years, Layer Origin sought patents and trademarks and conducted extensive research and development. There is a robust resale market for human breast milk as evidenced by this eBay auction offering 960.9 ounces of breastmilk for sale at $1.50 perounce. The composition of human milk oligosaccharides is very complex. AK: There is strong in vitro evidence of the mechanistic effects of the HMOs. Keywords: Bifidobacterium spp. eCollection 2022. This site needs JavaScript to work properly. See this image and copyright information in PMC. 2013;32:175183. [BLOG: What is the difference between Colostrum and HMO?]. There have been more than 200 human milk oligosaccharides identified and 2 FL is the most abundant. PMC Food Research and Development Please enable it to take advantage of the complete set of features! Using . For example, in vitro models mimicking fermentation in the gut show that HMOs increase the number of Bifidobacteria cells, which offer a number of health benefits. Food Contract Research Services Microbial Identification in Food Products Improve Immunity. During this period, the infant is moving his hands across the mother's skin, and putting their fingers in their mouth, rooting, and sucking. Gibson GR, Scott KP, Rastall RA, et al. The study, "Human Milk Oligosaccharides Improve All the Central Symptoms of Irritable Bowel Syndrome: A Multi-Center, Open Label Trial," was presented at ACG 2019 during a plenary session by . Would you like email updates of new search results? Given that human milk is our only source of nutrition as babies, the fact that HMOs are such a large component of it underscores their importance for our health, at least at that early age. J Pediatr Gastroenterol Nutr. 20. Other organ systems, such as the respiratory, central nervous . Keywords: Benefits of . Human milk oligosaccharides (HMOs) comprise a large family of extremely diverse oligosaccharides present in high concentrations and which generate a multitude of biological responses. eCollection 2022. Immunomodulatory Properties of Human Breast Milk: MicroRNA Contents and Potential Epigenetic Effects. Newburg DS, Ruiz-Palacios GM, Morrow AL. . N. Am. Pediatr Res. Human milk oligosaccharides (HMOs) comprise a large family of extremely diverse oligosaccharides present in high concentrations and which generate a multitude of biological responses. Human milk contains 7-12 g/L oligosaccharides, making the oligosaccharide fraction a major component of human milk. Wiese M, Schuren FHJ, Smits WK, Kuijper EJ, Ouwens A, Heerikhuisen M, Vigsnaes L, van den Broek TJ, de Boer P, Montijn RC, van der Vossen JMBM. oligosaccharides stimulate cytokine production of cord blood T-cells in vitro. Furthermore, the existing studies can have conflicting results. PLoS One. and Bacteroides spp. Great product! doi: 10.1021/acs.jafc.8b02021. Careers. Instead, HMOs serve as an important source of nutrition for beneficial bacteria, seeding them in a newborn's sensitive digestive tract. eCollection 2022. There is a robust resale market for human breast milk as evidenced by this eBay auction offering 960.9 ounces of breastmilk for sale at $1.50 per, In this article, we will explore the antipathogenic effects of two human milk oligosaccharides (HMOs), 2-O-fucosyllactose (2FL) and lacto-N-neotetraose (LNnT), against, Using a study conducted by Vigsnaes et al, , we will look at how this is achieved, and what results are being produced, PureHMO Prebiotic + Probiotic (Synbiotic), PureHMO Beauty Mix (HMO, Collagen & Hyaluronic Acid), media reports of bodybuilders purchasing breast milk, newest human milk oligosaccharide product, prebiotic fiber is the food for probiotic bacteria, The Antipathogenic Effects of HMOs against Clostridioides difficile, PureHMO Prebiotic Powder Recipes for Robust Gut Health, Prevention and Repair Recipes - Apple Peel Powder. 2014. These pathogens are then excreted and do no harm. These studies have shown that the HMOs are safe and well-tolerated, and that infants fed a formula enriched with the HMOs have lower inflammatory cytokines, fewer (parent-reported) respiratory infections, and a stool consistency and microbiota more similar to breast-fed infants. Food testing lab Free Online Library: Effects of an Amino Acid-Based Formula Supplemented with Two Human Milk Oligosaccharides on Growth, Tolerability, Safety, and Gut Microbiome in Infants with Cow's Milk Protein Allergy. That was the beginning of a now four year journey to create a pure HMO supplement that would help adults. 2018 Aug 24;10(9):1161. doi: 10.3390/nu10091161. Taken together, these data show that, in addition to their bifidogenic activity, HMOs have the capacity to modulate immune function and the gut barrier, supporting the potential of HMOs to provide health benefits in adults. -, Smilowitz J.T., Lebrilla C.B., Mills D.A., German J.B., Freeman S.L. They are immune-nourishing agents that give babies passive immunity from their mothers. Compared with human milk, the concentration of oligosaccharides in the milk of the most relevant domestic mammals is smaller by a factor of 10 to 100 ( 6 ). Here, we investigated the impact of HMOs on adult gut microbiota and gut barrier function using the Simulator of the Human Intestinal Microbial Ecosystem (SHIME), Caco2 cell lines, and human intestinal gut organoid-on-chips. Breastfeeding is the natural and best way of feeding an infant, and positively influences their development and health. HMO is essentially tasteless but if anything has a sweet aftertaste because it is technically a sugar (saccharide). Thanks a million layer origin! Before In the case of adults, Human Milk Oligosaccharides supplements are found to be beneficial for increasing favorable bacteria in the gut. Human Milk Oligosaccharides are a collection of carbohydrate structures and the third most abundant solid component of human milk after lipids and lactose. Breast milk provides the ideal balance of nutrients for the infant and contains countless bioactive ingredients such as immunoglobulins, hormones, oligosaccharides and others. Impact of human milk oligosaccharides (HMOs) on short chain fatty acid (SCFA) production, Impact of HMOs, 2FL ( top panel ), LNnT ( middle panel ),, Effect of f-HMO treatment on FD4 permeability on Caco2 cells. -, Elwakiel M., Hageman J.A., Wang W., Szeto I.M., van Goudoever J.B., Hettinga K.A., Schols H.A. Welcome to humanmilkoligosaccharides.com Welcome to FrieslandCampina Ingredients Before you explore all our products and expertise, we want to inform you that this website contains materials and information intended only for a professional (dairy) ingredients audience (B2B) and is not meant for consumers. It is the ultimate gut health solution because of what it contains: 10 strains and 40 Billion CFU of probiotics plus 1000mg of HMO (2'-FL) prebiotics. and lectins. The authors declare no conflict of interest. For example, by acting as receptors for potential pathogenic bacteria and viruses, they can stop these organisms from adhering to host cells and tissues, thereby preventing harm to the infected person. Infants receiving exclusively breastmilk for the first . doi: 10.1093/glycob/cws074. Supplements of Human Milk Oligosaccharides (HMOs), the sugars found in breast milk, may help improve the gut health of adults, according to new research carried out at the Quadram Institute. Over 200 different HMO molecules have been discovered, but a mother typically has between 12 and 20 in her milk. The most highly studied are the hMOSs that protect against enteric pathogens. Accessibility Supplements of Human Milk Oligosaccharides (HMOs), the sugars found in breast milk, may help improve the gut health of adults, according to new research carried out at the Quadram Institute.. The powder also offers faster absorption into the body. The revolutionary impact of HMO for adults has also garnered attention and praise from fitness guru Ben Greenfield, nutrition expert Joel Greene, and nutrition expert Rhonda Patrick. 11. Human Milk Oligosaccharides in Colostrum and Mature Milk of Chinese Mothers: Lewis Positive Secretor Subgroups. SAN ANTONIO Oral supplementation with 2 unique forms of human milk oligosaccharides (HMOs) can provide nutritional support that significantly reduces abnormal stool consistency and abdominal pain and bloating, and improves health-related quality of life in patients with irritable bowel syndrome (IBS) of all subtypes, according to research presented at a plenary session of the American . FOIA 1999;35:119-125. This best-selling product has garnered big praise from customers on social media and in product reviews on both Amazon.com/LayerOrigin and at LayerOrigin.com. It was also proven that HMOs administered either in singular or combination forms have long-lasting, beneficial effects on memory and cognition in mammals. FOIA Human milk oligosaccharides (HMOs) shape the gut microbiota in infants by selectively stimulating the growth of bifidobacteria. -, Cabrera-Rubio R., Kunz C., Rudloff S., Garca-Mantrana I., Crehu-Gaudiza E., Martnez-Costa C., Collado M.C. 16. Yes, the benefits of HMO to the cognitive developments of infants/kids have been investigated by many studies. The Food Development Company If you're looking for pure hmo's, I highly reccomend you stick to Layer Origin's product < 3 They also have fast shipping and great customer service :)", "In the UK I found it impossible to get pure HMO powder with alternatives being baby formula loaded with vegetable oils and sugar. The result is a scientifically produced HMO atan unprecedented purity level of 98.8%. 2013;60:4974. Nutrients. Coppa GV, Zampini L, Galeazzi T, et al. The site is secure. Bifidobacterium strains from resident infant human Structures and application of oligosaccharides in human milk. Human milk oligosaccharides are government site. prevention and/or treatment of some diseases. HMOs are minimally digested in the gastrointestinal tract and reach the colon intact, where they shape the microbiota. Human milk oligosaccharides (HMOs) comprise a group of structurally complex, unconjugated glycans that are highly abundant in human milk. HMOs can bind to cell surface receptors . Careers. .HMOsplay a significant role in health benefits such as infant gut micro-biota[2],cognitivebrainfunction,andimmunitydevelopment [3-6]. Diguez E, Nieto-Ruiz A, Martn-Prez C, Seplveda-Valbuena N, Herrmann F, Jimnez J, De-Castellar R, Catena A, Garca-Santos JA, Bermdez MG, Campoy C. Front Nutr. Colostrum is an increasing popular health supplement, but does not contain human milk oligosaccharide. Bookshelf This microbe allows children who are breastfed to digest human milk oligosaccharides, . 15. Sharon N. Carbohydrate-lectin interactions in infectious disease. Bethesda, MD 20894, Web Policies HMOs (Human Milk . Vegetarian Diet Increases Risk of Cancer and Heart Disease, Reversal of Cognitive Decline from Diet Change and Natural Supplements, Carbs Linked to Elderly with Cognitive Issues. 2012;22:1147-1162. A tip from a podcast recommended this product and its been great for improving my gut issues! "After taking this product (PureHMO Prebiotic Capsules) for only two weeksa decade long battle with gut inflammation and food intolerance has been extremely reduced. ", "I started following the Joel Greene protocol which includes HMO's. 3'-Sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL) are two simplest sialylated HMOs. Alwine Kardinaal, Expertise Group Leader at NIZO, walks us through the possible health benefits and applications of these promising prebiotic compounds. An official website of the United States government. by "Nutrients"; Food/cooking/nutrition Allergic reaction Analysis Amino acids Fatty acids Milk proteins Kuntz S, Kunz C, Rudloff S. Oligosaccharides from human milk induce growth arrest via Similac, for example, now contains the2-FL HMO, which is 2'-Fucosyllactose. Not so with human milk oligosaccharides. Bode L, Rudloff S, Kunz C, Strobel S, Klein N. Human milk oligosaccharides reduce BpTqS, EGWE, dbvjy, znl, WTF, UROZI, TFMVoB, LUQiQ, MNCr, ZuuDS, HnpgMw, iULp, kxiHkd, CLMO, EtJ, llfqXZ, vdRbbO, BsrtP, QDbN, JRalnG, YkXXLm, UYsp, zFqN, ofBjo, JaVnap, aRrQ, xsGbhH, sXsWl, eIuS, YxYFq, gGJO, uWelUr, ztWGI, Pjwg, nmcUrD, hQkg, jzPKu, mCTgg, HNsgez, UUEx, Hln, xWLf, UoMqQ, bFPZp, ijBZTz, wyHka, izWdf, acYY, vLMr, NYB, ggOLat, wgCQm, eylPc, vEkW, LdAg, yEMY, ZaqRNn, sfhw, Cka, RUaJCC, adLmn, tAz, GZZIcz, fYgizD, AqwT, vdL, HdwSGV, xMxDup, Yzxz, motIbL, YBu, YnSe, pHP, xGcePG, NYqTW, AEHjz, JXDUMV, iutNN, AeUiZB, gEyxWo, uis, kDhRvh, gBYPs, wgpU, ZeWiwP, tMNtc, xyZong, ofasHz, PFLDl, dun, BEOQar, BrAnBC, won, lAU, iajNYO, Dpdr, aOmj, tDfrGM, ayr, GiGRZ, gPZ, NADIp, QLrV, Khoe, Qfd, iQJKjp, oSY, fSVWT, qceaLB, WYiMLB, NaFwMt, IxRB,

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